I've recently built a new shop and house and have a number of the features you discussed and two years of experience living and working in the space. My workshop (and attached house and garage) are on one level, slab on grade with a hydronic heating system. There's a simple shed roof with ceiling heights of 10 feet on the low side and 16 feet at the peak (building is 24 feet wide). By building a box with a shed roof construction costs were kept down, for example the roof is framed with 2x14 LVL's at 24 inches on center, spaning the entire 24 foot width. By using a 2 foot module material waste was kept to a minimum. Wall framing are 2x6's on the low wall and 4x6 on the high wall for structural reasons.
In the workshop lighting is from high bay LED pendant lights (bottom of lights are 10 feet above the floor) which give more than enough light, and is supplemented where needed with task lighting. One feature I really appreciate is the hydronic system, it's silent and the space has a nice, even heat. There is a small wood burning stove to supplement the heat, and dispose of scrap wood and sawdust, plus a ceiling fan to circulate the warm air. South facing windows are designed to let sun in during the winter months and shades the sun during summer months. On the north side there are floor to ceiling windows that let in even north light, and the view of Mt. St. Helens (I'm in SW Washington). Garage doors are 9 feet tall, aluminum with frosted glass that lets in light, but conceals what's inside the garage. There are seals all around the garage doors that keeps cold, wind, rain, and snow out. In addition the garage door tracks are parallel to the sloping ceiling, thus increasing headroom. Instead of a traditional chain driven garage door opener there is a direct drive wall mounted motor, much quieter, takes up less space, and has a battery backup in case the power goes out.
One feature I strongly suggest are having floor outlets with cover plates. They supply power to most of my tools that are located in the center of the shop. My advice is to take the time to think about what you want to achieve with the space and design the space to realize those goals. Plus consider longer term uses and how the space may accommodate those uses. In my case I'm retired and aging, so there are no floor level changes, adding to my long term safety and comfort.