In general, the only time I ever clamp my rails is when doing a bevel cut. The foam grips hold the rail in place from the force of pushing downward on the saw itself, but if your plywood is pretty warped, it may not make enough contact.
I cut all kinds of things, from HPL sheets, solid surface, and acrylic, as well as wood sheet products successfully, with nothing but the rail.
A rail square may give you enough additional friction to keep the rail still.