Yes, definitely "one of those".
The only place where it's really an issue is with corded drills. The palm of a left hand goes right across the trigger lock, so if the bit grabs, two problems happen at once. First, the motor is still running, which is bad enough, but it is also trying to spin out of your hand. For a righty, the grip actually pushes harder into your hand.
Like I said, even though the smaller OFs have a trigger type switch, it doesn't bother me, because I don't use it like that.
The thing about being a lefty is that you are always having to adapt, so it just becomes a way of doing things. Since virtually everything is built for right handers, when they do run into a situation where they have to do something backwards, it's a much bigger issue.
They do have one of the big 3HP Porter-Cable plunge routers over in the solid surface department and I have used it a few times while helping out. It has he trigger in the right handle, but it doesn't bother me because I have both hands on it anyway. The grips are symmetrical, so it doesn't feel odd. I couldn't use the 1010 or 1400 with the opposite hand though.