I think you are overthinking it. With metal ball-bearing slides, it will be fine. I have done drawers in as many configurations are you would care to count. Wide, short, angled faces, radius faces, you name it. Angled faces where the slides are several inches out of square to the back of the cabinet are rather wild looking.
The one under the end of my assembly table is 40" wide, 20" deep, and pretty well overloaded.
They all open just fine.
The reddish looking one in the pic was 5 degrees out of square. That made it close enough to keep the guide equal. The curved one was off a lot more. It required 2 different lengths and you still had to engage one side long before the other.
The want to go straight, the enemy of drawer guides is being too tight. Most of the side mount sets will tell you to make the drawer 1" smaller than the opening, taking an additional 1/16" helps.